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Home > Products >  99% Powder Promethazine Hydrochloride for Treatment of Allergic Disorder CAS NO.58-33-3

99% Powder Promethazine Hydrochloride for Treatment of Allergic Disorder CAS NO.58-33-3 CAS NO.58-33-3

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  • FOB Price: USD 1600 /Kilogram Get Latest Price
  • Min.Order: 10 Gram
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  • Best price of Promethazine Hydrochloride
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  • 10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-, monohydrochloride factory

Quick Details

  • ProName: 99% Powder Promethazine Hydrochloride ...
  • CasNo: 58-33-3
  • Molecular Formula: C17H21ClN2S
  • Appearance: white powder
  • Application: the product is an antihistamine for al...
  • DeliveryTime: 15 days
  • PackAge: 25 KG / PP bag
  • Port: Tianjin
  • ProductionCapacity: 1000 Metric Ton/Month
  • Purity: 99%
  • Storage: dry place
  • Transportation: By shipment
  • LimitNum: 10 Gram
  • Moisture Content: 0
  • Impurity: 0
  • 0: 0

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Details

details

 

usp standard anti-allergic raw powder promethazine hydrochloride
 
 
quick detail
 
product name
promethazine hydrochloride
synonym
 
promethazine hcl;promethazine hydrochloride;phenrgan
 
cas no
 
58-33-3
 
mf
 
c17h21cln2s
 
mw
 
320.88
 
einecs
 
200-375-2
 
purity
 
99%
 
appearance
 
white powder
 
melting point

230-232°c

standard
 
usp
 
grade
 
pharma grade
 
usage
 
antihistaminic, antiemetic, cns depressant
 
usage
 
for the treatment of allergic disorders,and nausea/vomiting
 

 

what is promethazine hydrochloride
 
promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family.the drug has strong sedative and weak antipsychotic effects. it also reduces motion sickness and has antiemetic and anticholinergic properties (via its action on the dopamine receptor d2). in some countries it is prescribed for insomnia when benzodiazepines are contraindicated. it is available in many countries under many brand names.
 
promethazine was developed in the mid 1940s when a team of scientists from rhône-poulenc laboratories were able to synthesize it from phenothiazine and a diamine side chain of diphenhydramine
 
promethazine hydrochloride occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. it is soluble in water and freely soluble in alcohol.
 
each tablet, for oral administration, contains 25 mg or 50 mg of promethazine hydrochloride. in addition each tablet contains the following inactive ingredients: dibasic calcium phosphate, magnesium stearate, microcrystalline cellulose, sodium starch glycolate and stearic acid.
 
promethazine hydrochloride tablets usp, 50 mg also contain anhydrous lactose.
 
 
application of promethazine hydrochloride
 
promethazine is used to prevent and treat nausea and vomiting related to certain conditions (such as before/after surgery, motion sickness). it is also used to treat allergy symptoms such as rash, itching, and runny nose. it may be used to help you feel sleepy/relaxed before and after surgery or to help certain narcotic pain relievers (such as meperidine) work better. it may also be used for a short time to treat a runny nose due to the common cold.
 
promethazine is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain.
 
 
usage of promethazine hydrochloride
 
perennial and seasonal allergic rhinitis.vasomotor rhinitis.
 
allergic conjunctivitis due to inhalant allergens and foods.mild, uncomplicated allergic skin manifestations of urticaria and angioedema.
 
amelioration of allergic reactions to blood or plasma.dermographism.
 
anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled.
 
preoperative, postoperative, or obstetric sedation.prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery.
 
therapy adjunctive to meperidine or other analgesics for control of postoperative pain.sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused.
 
active and prophylactic treatment of motion sickness.antiemetic therapy in postoperative patients.
 
promethazine hydrochloride
cas no.: 58-33-3
synonyms:

10h-phenothiazine-10-ethanamine, n,n,α-trimethyl-, monohydrochloride;

promethazine hydrochloride; promethazine hydrochloride;

formula:

c17h21cln2s

exact mass: 320.11100
molecular weight: 320.88000
psa: 31.78000
logp: 5.10640
properties

appearance: white or off white powder
density: 1.131 g/cm3
melting point: 230-232ºc
boiling point: 403.7ºc at 760 mmhg
flash point: 198ºc
storage condition: keep in a cool, dry, dark location in a tightly sealed container or cylinder. keep away from incompatible materials, ignition sources and untrained individuals. secure and label area. protect containers/cylinders from physical damage.


description


  • promethazine hydrochloride is a racemic compound.
  • promethazine hydrochloride, a phenothiazine derivative, is designated chemically as 10h-phenothiazine-10-ethanamine, n,n,α-trimethyl-, monohydrochloride, (±)-with the following structural formula:
  • promethazine hydrochloride occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. it is soluble in water and freely soluble in alcohol.
  • promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family. the drug has strong sedative and weak antipsychotic effects. it also reduces motion sickness and has antiemetic and anticholinergic properties (via its action on the dopamine receptor d2). in some countries it is prescribed for insomnia when benzodiazepines are contraindicated.
 

details

 
promethazine hydrochloride quick detail
 
product name:
promethazine hydrochloride
synonyms:
10-(2-dimethylamino-1-propyl)phenothiazine hydrochloride;promethazine hcl;promethazine hydrochloride;phenergan;10-(2-(dimethylamino)propyl)phenothiazinemonohydrochloride;10-(2-(dimethylamino)propyl)-phenothiazinmonohydrochloride;10-(2-dimethylaminopropyl)phenothiazinehydrochloride;10-(3-dimethylaminoisopropyl)phenothiazinehydrochloride
cas:
58-33-3
mf:
c17h21cln2s
mw:
320.88
einecs:
200-375-2
 
what is promethazine hydrochloride
 
promethazine hydrochloride is a prescription drug. it's available as an oral solution, a rectal suppository, and an oral tablet.
 
the rectal suppositories are available as the brand-named drugs phenadoz, phenergan, and promethegan. they are also available as generic drugs. the oral solution and oral tablet are only available as generic drugs. generic drugs usually cost less. in some cases, they may not be available in every strength or form as the brand-name version.
 
this drug may be used as part of a combination therapy. this means you may need to take it with other medications.
 
promethazine hydrochloride application
 
the dose of promethazine depends on the condition being treated. typical doses range from 12.5 mg to 25 mg, and may be taken once daily or several times per day, as prescribed. promethazine may interact with cold or allergy medicine, sedatives, narcotics, sleeping pills, muscle relaxers, medicine for seizures, depression, lithium, atropine, belladonna, benztropine, dimenhydrinate, methscopolamine, scopolamine, blood pressure medications, blood thinners, bronchodilators, bladder or urinary medications, mao inhibitors, medicines to treat parkinson's disease, restless leg syndrome, or pituitary gland tumor, medicines to treat stomach ulcer or irritable bowel syndrome. many other medicines can interact with promethazine. tell your doctor all medications and supplements you use. during pregnancy, promethazine should be used only if prescribed. it is unknown if this drug passes into breast milk or if it could harm a nursing baby. consult your doctor before breastfeeding.
 
our promethazine hydrochloride suppositories side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
 
promethazine hydrochloride specification
 
test items
specification
test results
description
white crystalline powder
white crystalline powder
identification
ir , uv
confirm
loss on drying
≤0.5ml
0.21ml
residue on ignition
not more than 0.2%
0.06ml
iron
not more than 0.005%
0.0018%
heavy metals
not more than 0.001%
0.0006%
related substances
total:not more than 1.0%
individual:not more than 0.5%
0.32%
0.14%
e-isomer
not more than 0.3%
0.19%
organic volatile impurities
conforms
conforms
assay
99.0~101.0%
99.51%
conclusion
conform with usp30
 

quick detail

 
product name
promethazine hydrochloride
synonym
 
promethazine hcl;promethazine hydrochloride;phenrgan
 
cas no
 
58-33-3
 
mf
 
c17h21cln2s
 
mw
 
320.88
 
einecs
 
200-375-2
 
purity
 
99%
 
appearance
 
white powder
 
melting point

230-232°c

standard
 
usp
 
grade
 
pharma grade
 
usage
 
antihistaminic, antiemetic, cns depressant
 
usage
 
for the treatment of allergic disorders,and nausea/vomiting
 

packaging & delivery:

1. mass stock: to make sure delivery promptly every day when the payment is done.
2. rich experience: we have sophisticated and professional logistics department, which can guarantee safe and speedy delivery.
3. professional team: well-trained and disciplined team which is professional enough to provide you a safe package. unique ways to ship 10 grams to 20 kilograms powders (or 100ml to 30 liter liquids) at one time to your destination.
4. logistics information:packing pics and tacking number are provided within 12 hours after we confirm your payment. updated tracking information will be provided every other day just for you can hold a palm of your package.
5. perfect after-sale service: any questions or problems after receiving the product, please feel free to contact us. problems would be solved immediately.

 
 
how to order


1, please kindly tell us what you need. then more competitive price will be offered.
2, we will pack your powder and delivery it within 12 hours after confirming your payment.
3,the packaging photo of your powder will be sent, folling is the tracking number.
4, waitting receiving your parcel in 4-7 days after having tracking number. during this time, you can trace your parcel tracking number online.
5, confirm the powders you received.

 
 

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